The horrific accident involving Khalwale's family occurred at Kaimosi.
The vehicle, which had veered off the road, hit a banana tree before it landed by the roadside.
The Kakamega Senator went to Twitter to thank God for the safety of his family.
Khalwale tweeted: "My wives & I thank God for saving our 4 children in this afternoon's accident at Kaimosi. Kudos my brave son Tigana for controlling the car."