Mohamed Salah
Uruguay fielded a strong line up with superstars Edison Cavani and Luis Suarez named in their starting line up, while Salah was given a spot among the substitutes.
The first half ended goalless with Egypt in the ascendancy even without their talisman on the pitch.
Gimenez rose highest to convert a cross by Carlos Sanchez in the 89th minute to give Uruguay a 1-0 win in the group A fixture.
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No Salah as Uruguay beat Egypt 1-0
Twitter was not impressed as Hector Cuper left Liverpool forward Mohamed Salah on the bench for all 90 minutes of the encounter.
Cuper made three changes in the second half but refused to risk Salah who suffered a sever shoulder injury in the 2018 UEFA Champions League final against Real Madrid.
Reactions to Egypt's 1-0 loss to Uruguay
Some supporters were of the opinion that Cuper was right to keep Salah on the bench if he was not yet fully fit.
A fan said, "No Salah is the right call. As tempting as it is to go for this game, this is smart to get him more rest for rest of the group stage, which will be critical to advancing."
Some other supporters also said even though Salah was not available Egypt played well.
Another supporter said, "No Salah but still Egypt played well."
'No Salah' was among the trends on Twitter with several users adopting different captions, such as 'No Salah No success', 'No Salah No Party' 'No Salah No win'.
Salah had an excellent season with Liverpool as the supporters were of the opinion that Salah will have made a difference if he was afforded some minutes on the pitch against Uruguay.
Luis Suarez mocked on Twitter after Uruguay beat Egypt 1-0
Luis Suarez showed signs of frustration as he was guilty of missing several chances for Uruguay.
Twitter users were not impressed with his antics during the encounter with Egypt as he was criticised for acting upon a challenge.
A fan said, "Luis Suarez is a class A idiot. Rolling around like an absolute idiot.Shocking player honestly. Wonder how his kids show their face at school after all this."
He was given the award of the best actor following his theatrics after contact with the Egyptian player.
Uruguay take on Saudi Arabia in their next fixture while Egypt will hope Salah is fit for their next game against hosts Russia.