Reiner later formed a comedy duo with Mel Brooks, and the duo appeared in movies like 1963's It's a Mad, Mad, Mad, Mad, World and the 2007's Ocean's Thirteen. The legendary actor earned one Grammy and nine Emmys during his career, and he's the father of actor and director Rob Reiner, author and playwright Annie Reiner, and photographer and painter Lucas Reiner.

Here's how Hollywood is reacting to Reiner's death.

Rob Reiner posted a heartbreaking tweet in which he called his dad his guiding light:

Last night my dad passed away. As I write this my heart is hurting. He was my guiding light. Rob Reiner (@robreiner)

Alan Alda said that Reiner's talent would "live on for a long time":

My friend Carl Reiner died last night. His talent will live on for a long time, but the loss of his kindness and decency leaves a hole in our hearts. We love you, Carl. pic.twitter.com/QWyNOYILhW Alan Alda (@alanalda)

Andrew Cuomo pointed out that Reiner was "Bronx born and bred":

Carl Reiner, Bronx born and bred, made TV comedy that endures to this day. He made America laugh a true gift. New York extends our condolences to his family and many friends. https://t.co/Xmou8kabLI Andrew Cuomo (@NYGovCuomo)

William Shatner said it was a pleasure to have known Reiner:

Condolences to the family of Carl Reiner. From the writers room of Sid Caesar to recreating those times for the Dick Van Dyke show, Carl was a master at his craft. I knew him only peripherally but it was a pleasure to have known him. William Shatner (@WilliamShatner)

NFL and college reporter Antwan Staley called Reiner a comedy legend:

We lost a comedy legend today. Reiner was best known as the creator, producer, writer, and actor on The Dick Van Dyke Show. He also co-wrote and directed some of Steve Martin's most successful films, including The Jerk (1979). R.I.P. https://t.co/DsMcZMob4N Antwan V. Staley (@antwanstaley)

Brian Heater pointed out Reiner's support for Black Lives Matter:

A picture of Carl Reiner with daughter Annie and recent birthday boy, Mel Brooks all in Black Lives Matter shirts. Fourteen hours ago, he tweeted a multi-part appreciation of Noel Coward. Reiner turned 98 in March. That's a lot of time spent being a good human. pic.twitter.com/Da1mmPpeFM Brian Heater (@bheater)

Rolling Stone TV critic Alan Sepinwall posted a video of Reiner with Mel Brooks:

RIP, Carl Reiner. An absolute giant of 20th century comedy. Part of Sid Caesar's hall of fame writers room, created The Dick Van Dyke Show, directed The Jerk, and was an all-time straight man with best friend Mel Brooks: https://t.co/SZ1nb80Ok4 Alan Sepinwall (@sepinwall)

Mia Farrow called Reiner brilliant and kind:

We lost a person who gave us great times-countless laughs. He was brilliant. And kind. I met him only once but will never forget his gentle thoughtfulness. He was with us through good times and hard times. Thank you Carl Reiner. His memory will be a blessing. . https://t.co/hbfPrO0eRe Mia Farrow (@MiaFarrow)

Jon Cryer shared the hilarious letter Reiner sent him when he hosted the Directors Guild awards:

The brilliant and hilarious Carl Reiner hosted the Directors Guild awards for decades before his health forced him to take the night off. They asked me to sub in for him. Heres the letter he sent me: #RIPCarlReiner https://t.co/dkvtzXtKfA pic.twitter.com/eUy2E9b0B0 Jon Cryer (@MrJonCryer)

Michael Schur said that Reiner was one of comedy's greatest magicians:

The Dick Van Dyke Show debuted in 1961, and it's still funny. That's a magic trick. RIP Carl Reiner, one of comedy's greatest magicians. Ken Tremendous (@KenTremendous)