The UN chief will hold talks with Israeli leaders, travel to Ramallah to meet Palestinian leader Mahmoud Abbas and to the Gaza Strip, where the United Nations runs a major Palestinian aid program, during the three-day visit beginning August 28.
Israel's UN Ambassador Danny Danon said the visit will allow Guterres to "build a relationship" with Prime Minister Benjamin Netanyahu and that he will also hold meetings with the Israeli president and defense minister.
"We are very happy about this visit," Danon told AFP.
"It's a great opportunity for the secretary-general to experience Israel, to meet the leaders of Israel and to understand the challenges that Israel faces day-in and day-out."
The Israeli government will discuss strengthening the mission of the UN interim force in Lebanon (UNIFIL), said Danon, following a series of skirmishes along the UN-monitored demarcation line between Israel and Lebanon.
The visit comes as diplomatic efforts to revive Israeli-Palestinian peace talks appear deadlocked.
Guterres, a former prime minister of Portugal, "is experienced. He has been to Israel in the past. He knows the complexity of the issues. He is not someone who comes to our region and has no clue about what is happening," said Danon.
Relations between the United Nations and Israel have been tense over the expansion of Jewish settlements, which the world body has condemned as illegal.
Since taking over from Ban Ki-moon on January 1, Guterres has been cautious in his approach to the Israeli-Palestinian conflict, partly in response to US accusations that the United Nations was biased against Israel.
In March, the UN chief demanded that a report by a UN body be withdrawn after it accused Israel of imposing an apartheid system on the Palestinians.
Guterres had initially distanced himself from the report, but the United States insisted that it be withdrawn altogether.
During the recent flareup of violence in Jerusalem, Guterres called for de-escalation and respect for the status quo at holy sites after Israel installed metal detectors at the Haram al-Sharif mosque compound, known to Jews as the Temple Mount.
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