What we know about UK terror attack
The bombing is the latest in a string of attacks that have hit Europe in recent years, several claimed by the Islamic State group.
Here is what we know so far about the terror attack, the deadliest in Britain since 2005.
Police said they were called at 10:33pm (2133 GMT) to reports of an explosion at Manchester Arena during a concert by pop star Ariana Grande, who is popular with teenagers and pre-teens.
According to police, the blast occurred "within the foyer area of the stadium", although the venue said it was in a public area outside. Prime Minister Theresa May said it was near one of the arena exits.
The arena foyer connects the 21,000-capacity auditorium with Victoria train and tram station, a major transport hub on the northern edge of the city centre. It remained closed on Tuesday lunchtime.
Witnesses described a "huge bomb-like bang" and scenes of panic as young fans rushed out and parents waiting outside searched frantically for their children.
Authorities are treating the attack as a terrorist incident, but no one has so far claimed it.
Police chief Ian Hopkins had said earlier that a sole attacker had set off an "improvised explosive device" and died in the process.
May revealed that police know the attacker's identity but would not yet confirm it publicly, adding: "They now need to know whether he was acting alone or as part of a wider group."
Manchester police later announced the arrest of a 23-year-old man in the south of the city, saying only that it was connected to the investigation into the attack.
Britain's threat level remains at "severe", meaning an attack is highly likely, but this will remain under review, May said.
At least 22 people were killed and 59 injured, including "many children and young people", May said.
Georgina Callander, 18, was the first victim to be named after her school, the Runshaw College Sixth Form Center in Lancashire, confirmed the news on its Facebook Page.
"It is with enormous sadness that it appears that one of the people who lost their lives in Monday's Manchester attack was one of our students here," it said, adding that she was studying health and social care.
The prime minister condemned the attack for its "appalling sickening cowardice" and for "deliberately targeting innocent defenceless children and young people".
The incident is Britain's second terror attack in less than two months.
On March 22, five people were killed and more than 50 injured when a man drove into pedestrians on Westminster Bridge in central London, before crashing into the fence surrounding parliament.
The attacker, 52-year-old Khalid Masood, fatally stabbed a police officer before being shot dead by police outside the Houses of Parliament.
Investigators described it as "Islamist-related terrorism" but said they may never know why he did it and have not charged anyone else in relation to the incident.
The deadliest bomb attack on British soil took place on July 7, 2005 when four British suicide bombers inspired by Al-Qaeda attacked London's transport system, killing 52 people and wounding 700.
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